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Welcome to the Wright Lab

Department of Biomedical Informatics
University of Pittsburgh


The Wright Lab uses experimental evolution and comparative genomics to study how microorganisms fight for survival. In particular, we seek to tackle the problem of antibiotic resistance through understanding the evolution of both antibiotic-producing microbes and antibiotic-resistant pathogens.

Four fundamental questions motivate research in the lab:
  • How do naturally antibiotic-producing bacteria ward off resistance?
  • How do genomes evolve to compensate for newly acquired traits?
  • What is the optimal strategy for treating bacterial pathogens in the clinic?
  • What is the role of spatial organization in shaping the adaptive landscape?

Our lab is composed of interdisciplinary scientists who complement computing with laboratory experiments. We have open positions for postdocs, graduate, and undergraduate students with interests in evolution, microbiology, bioinformatics, and quantitative biology.